Metabolic regulation of protein post-translational modification (PTM) is an emerging field of biochemistry and molecular biology. PTM is a reversible process, which can dynamically regulate the metabolic state of cells through regulation of protein structure, activity, localization, or protein-protein interactions. The dynamic regulation of PTMs also could be modified in response to nutrient availability, hormone stimulation, and cell differentiation under different physiological conditions. This session will highlight recent advances showing the relationship between protein PTM and cellular metabolism from the viewpoints of lysine and histidine modification and sirtuins.
Epigenetics has emerged as one of the most fundamental regulatory mechanisms of gene expression and cellular functions. Without changes in genetic information, this provides a regulatory tool playing an essential role in cellular differentiation, aging, and disease susceptibility. Main fields of epigenetic study include DNA methylation, histone modifications, and small and long non-coding RNAs. In this session, four speakers will discuss about the recent advances and tools in epigenetic gene regulation.
This session will cover applications of various single-cell omics technologies for understanding cellular development and disease pathogenesis.
This session is organized to provide structure-based understanding of bio-molcular mechanism.
Next generation sequencing (NGS) techniques enabled us to understand human diseases at the genome level. Now NGS techniques are applied for the diagnostic tests in precision medicine clinic to match targeted and immuno-therapy in individual patients. Speakers in this session will cover the new techniques for liquid biopsy based on RNA sequencing and digital PCR, and also the clinical utility of NGS in clinical trials for immunotherapy.
Most metabolic studies depend heavily on abundance of mRNAs and proteins of enzymes and metabolites implicated in the metabolic pathways of interest without obtaining actual metabolic rates (“dynamics”) when exploring dysregulation of metabolic pathways. Knowing the fact that enzymes in metabolic pathways are heavily regulated by numerous factors including allosteric feedback and substrate availability, the sole dependence of metabolic (pathway) study on such “static, snapshot” information can lead to erroneous conclusions, with ample evidence of such disagreement between snapshot and dynamics. Thus, it is of critical value to learn from leading experts in the field of “metabolic dynamics” in humans and model organisms how to obtain and use metabolic dynamics in metabolic research (i.e., in vivo and in vitro metabolic flux tracing with stable isotope tracers), which enables basic and clinical researchers to make a great progress in diverse research.
Recent discoveries showing that various mRNA chemical modifications can affect RNA metabolism including decay, transport, splicing, and translation in cell type- and tissue-specific manner, leading to the emergence of the field of epitranscriptomics. In addition, accumulating evidences showed that epitranscriptomic mechanisms play critical post-transcriptional regulatory roles in development and etiology of many human diseases. In this session, we will discuss about recent advances in our understanding of epitranscriptome and how alterations in RNA regulatory programs lead to human diseases.
COVID-19 is an ongoing pandemic disease caused by infection with SARS-CoV-2. To develop effective vaccines and therapeutics, a better understanding of the immune responses against SARS-CoV-2 is needed. In this session, our recent understanding of COVID-19 and immune responses will be discussed.
Traditional therapeutics against human diseases have been designed to inhibit the enzymatic activity or compete for the ligand binding sites of pathological target proteins. Despite its demonstrated effectiveness, this approach is often limited by recurring drug resistance, and more importantly, not all disease targets are 'druggable' that can be directly occupied by active site-directed inhibitors. Recently, a promising new paradigm has been created, in which small-molecule chemicals harness the naturally occurring protein quality control machinery of the ubiquitin-proteasome system (e.g. PROTACs) and lysosomal degradation pathways (e.g. AUTOTACs & LYTACs) to specifically eradicate disease-causing proteins in cells. Such ‘chemically induced proteolysis’ may provide unprecedented opportunities for targeting proteins that are inherently 'undruggable', but instead 'degrdadable', for therapeutic purposes. Aside from the topic of chemically induced proteolysis, this session will also highlight recent great interest of chemically modulated protein degradation in health and disease.
This session invites four prominent speakers from domestic and foreign country. All the speakers have studied important issues in the cardiovascular biology field. They will tell us about novel signaling networks in the vascular smooth muscle cells and endothelial cells, which are critical for human vascular diseases including athersclerosis.
Reward system is critical to coordinate and control motivated behavior which may ultimately be important not only for reward value cognition but also for adaptive behavior to react and cope with changes in the environment. The goal of this symposium session is to present recent progress towards an integrated understanding of brain circuit and signaling of different panel of reward-related behaviors. Speakers in this symposium will discuss their recent findings on neuromodulatory signaling and synaptic change/remodeling in food- or addictive drug-seeking behaviors as well as social reward-related behavior, such as social dominance, thereby offering the possibility to contrast differences and commonalities among different rewarding stimuli.
Stem cell-derived therapeutics are at the forefornt of regenerative medicine and provide new approaches to unmet medical needs. This session reviews recent progress of stem cell biology and regenerative medicine. Speakers are leading sciences of stem cell research fields: stem cell-derived organoids and tissue engineering, disease modeling and drug toxicity analaysis, tissue regeneration, and regulation of stemness. This session will help attendees to understand recent advances in stem cell research field.
Aging is a fundamental biological process that is associated with gradual declines in biological structure and function. In this symposium, four excellent scientists will present their research on mechanisms by which genetic and environmental factors modulate aging processes and age-related diseases at the cellular and organismal levels. David Vilchez and Seung-Jae V. Lee will give talks regarding the role of proteostasis and RNA homeostasis in organismal aging and stem cell aging. Yun-Sil Lee and Jin-Hong Kim will pressent their work on molecular dissection of age-associated diseases in bones and connective tissues. Overall this symposium will cover exciting progresses in the regulation of aging and age-related sieases in various aspects, which are crucial for promoting healthy human longevity in this aged society.
세포외기질은 암미세환경에서 염증세포의 이동을 도와주는 통로 역할 뿐 아니라 염증세포 및 기질세포가 생성하는 다양한 성장인자의 창고 기능을 수행하고 있다. 또한 이들 세포외기질이 효소에 의해 분해되면 성장인자를 포함한 매개체들이 노출되어 암세포 성장 및 염증/면역반응을 유도함과 동시에 유리된 세포외기질이 화학유인물질로 작용하여 염증반응을 증폭시킨다. 이처럼 세포외기질은 암미세환경 내에서 암세포의 성장 및 염증반응의 조절에 중요한 역할을 하고 있어 이에대한 중요성이 점점 더 커지고 있다.